• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    device and method for loading implant into the delivery system. the present invention relates to a device and method for loading an implant into a delivery system describing which are capable of simplifying operations required in interventional surgery using the implant. the device includes a guide cap (1), an actuator (2) and a guide tube (3). the guide cap (1) has a conical section (101) and a straight or conical tube (103) in communication with a small open end (102) of the conical section, and the conical section has a large open end (104) which spreads outwards, thereby forming a bead (105) facing the tube (103). the driver (2) has tapered sections (9, 10) that are tapered along an axis of the orienter, thereby forming large and small open ends (8, 11). the small open end (11) has a diameter greater than the diameter of the small open end (102) of the tapered section of the guide cap (1). the guide cover (1) and the guide (2) are thus of a determined size, that the flange (105) can cover and be engaged in the actuator (2), with a portion of the end of the straight or conical tube (103) protruding the small open end (11) of the actuator (2). the guide tube (3) is a round tube with two ends, the first open end having a diameter larger than the diameter of the small open end (102) of the conical section of the guide cap, and smaller than the diameter of the end small open (11) of the actuator.
    公开号:BR112016009486B1
    申请号:R112016009486-7
    申请日:2014-10-31
    公开日:2021-08-24
    发明作者:Xiang Liu；Mingming Wu；Yu Li；Zhixiu He；Baozhu Gui；Haishan Wang；Guoming Chen；Shaohui Chen；Qiyi Luo
    申请人:Shanghai Microport Cardioflow Medtech Co., Ltd；
    IPC主号:
    专利说明:

    TECHNICAL FIELD
    [0001] This invention relates to the device and method for loading implant in the delivery system. BACKGROUND
    [0002] Heart valve diseases are some of the most commonly diagnosed heart diseases in China, and some of them are found to be heart valve damage caused by rheumatic fever. In recent years in China, the continually aging population is prone to an increasing incidence of valve degeneration (including calcification, mucoid degeneration, etc.) and valve damage caused by metabolic disturbances.
    [0003] Minimally invasive interventional surgery offers a variety of advantages, including futility of sternotomy, minimal trauma to the patient, and rapid recovery. In the last ten years, development shows that not only diseases curable by traditional medical and surgical treatments, but also some diseases that traditional approaches may not control, can be treated by interventional therapies. After entering the twenty-first century, researchers in interventional therapies for valvular heart disease have experienced a remarkable acceleration. Percutaneous valve implantation techniques have evolved from experimental research to small-scale clinical trials, and are likely to have advances in technical "bottlenecks" to carry out extensive technical applications. This makes the techniques again a focus of research efforts in the field of interventional cardiology.
    [0004] CN101460115A describes a device for loading an interventional heart valve in a delivery system. The device is composed of a flow cone 42, a flow tube 38, a flow cone 34, a flow tube 40 and a cap 36. The interventional heart valve is crimped and inserted into the flow cone 34 with the help of cap 36 such that one end of the interventional valve is compressed by the flow cone 34. The flow tube 38 is then inserted through an opening of the cap 36 so that the compressed portion of the interventional valve is expanded to a a size that is comparable to a size of a delivery system catheter, thereby allowing an interventional valve stent to be attached to the delivery system. The delivery system is then manipulated to form a casing of the catheter and the outflow tube to move so as to allow the interventional valve stent to be partially loaded into the delivery system. Subsequently, the cap and the flow cone are retrieved, and the other end of the interventional valve stent is compressed into the flow cone. The remaining portion of the interventional valve stent is then reduced in size, and the delivery system is manipulated to receive the entire interventional valve stent. This device, however, requires complicated operations during its use in surgery. SUMMARY OF THE INVENTION
    [0005] It is thus an object of the present invention to provide a device and method for loading an implant into a delivery system, which can simplify operations required in interventional surgery using the implant. Other advantages of the present invention will be described below with reference to the embodiments.
    [0006] To this end, according to an aspect, the present invention provides a device for loading an implant into a delivery system. The device includes a guide cap, a guide and a guide tube. The guide cap has a conical section and a straight or conical tube, communicating with a small open end of the conical section. The tapered section has a large open end that spreads outwards and thus forms an edge. The orienter has a circumferential wall tapered along an axis of the orienter and thus forms a large open end at a first edge, and a second open end at a second edge of the circumferential wall. The small open end of the guide has a diameter greater than one diameter of the small open end of the tapered section of the guide cap. The guide cap and the guide are so sized that the rim is capable of covering the large open end of the guide, with an end portion of the straight or tapered tube protruding from the small open end of the guide. The guide tube is a round tube with a first and second open end, wherein the first open end has a diameter greater than the diameter of the small open end of the tapered section of the guide cap, and less than the diameter of the small open end. of the advisor.
    [0007] Optionally, the bead can define bevels, the orienter can have ridges on the first edge corresponding to the large opening edge, and ridges can match the bevels when the guide cover covers the orienter.
    [0008] Optionally, the bead can define an annular groove.
    [0009] Optionally, the advisor can have two tapered sections and the large open end and the small open end of the advisor can be formed into edges of two tapered sections; characterized by the fact that the large open end of a first of two tapered sections provides the large open end of the advisor; the small open end of the first of two tapered sections has a diameter equal to or slightly smaller than a diameter of a large open end of a second of two tapered sections, and is coupled to the large open end of the second of two tapered sections; and the small open end of the second of the two tapered sections provides the small open end of the advisor.
    [00010] Optionally, on the guide cap, a transition section is provided between the tapered section and the straight or tapered tube.
    [00011] Optionally, the guide tube can be a tapered tube or can consist of a straight tube section and a tapered tube section. A large open end of the tapered tube or tapered tube section provides the first open end of the guide tube.
    [00012] Optionally, the guide tube can have a transition section between the straight tube section and the tapered tube section.
    [00013] Optionally, the implant can be a heart valve stent.
    [00014] According to another aspect, the present invention also provides a method for loading an implant into a delivery system. The delivery system includes a catheter, a connector disposed at one end of the catheter, and a guide tip coupled to the catheter by a thin rod extending along an extended centerline of the catheter. The method is implemented by the device as defined above and includes: placing the implant in the advisor such that each end of the implant protrudes from a corresponding end of the advisor; covering the advisor with the guide cap such that the straight or conical tube of the guide cap extends through the implant, with the end portion of the straight or conical tube of the guide cap protruding from the small open end of the advisor; placing the guide tube over the delivery system catheter; advancing the tip of the delivery system guide into the straight or conical tube of the guide cap, and then coupling the implant to the delivery system connector and moving the delivery system catheter and guide tube, such that the implant is partially received in the catheter and, consequently, in the guide tube; arranging the large open end of the tapered guide cap section over the implant and advancing the implant into the straight or tapered guide cap tube, and then moving the guide tube so that the implant is fully received in the guide tube; and moving the catheter so that the implant is also entirely received in the catheter.
    [00015] According to the present invention, the loading of the implant is carried out with only three components of the device that are distinct in appearance without causing confusion, that is, the guide cap, the guide and the guide tube. Additionally, the slight contraction in the radial dimension of the guide in the middle portion allows the valve prosthesis to be encapsulated in that place without leaking and causing interruptions. Furthermore, the guide tube, which has a relatively large tapered tubular section at one end, or is fully implemented as a tapered tube, provides protection for the delivery system catheter, and allows for a larger tubular opening, which is adapted to loading more types of valve prostheses in various forms more easily without causing injury to them. All of these advantages are beneficial for smooth operations during clinical use of the device in surgery. Also, during the process of loading the implant into the distribution system, the guide cap allows the valve prosthesis to be coupled to the connector of the distribution system, and allows the valve prosthesis to be compressed so that it is fully capsulated in the distribution system with relatively easy and quick operations, thereby reducing the surgical time during its clinical use. BRIEF DESCRIPTION OF THE DRAWINGS
    [00016] The present invention will be better understood with reference to the accompanying drawings, provided without limiting the invention, characterized by the fact that:
    [00017] Figs. 1A, 1B and 1C schematically illustrate a guide cap in accordance with an embodiment of the present invention; Figs. 2A and 2B schematically illustrate a preferred embodiment of an adviser in accordance with an embodiment of the present invention; Figs. 3A and 3B are schematic illustrating a guide tube, in accordance with an embodiment of the present invention; Fig. 4 shows a valve prosthesis applicable to embodiments of the present invention; Fig. 5 shows the implant being received in the orienter, in accordance with an embodiment of the present invention; Fig. 6A and 6B show the gear of the guide cover and the guide, in accordance with an embodiment of the present invention; Fig. 7 shows the valve prosthesis engaging a delivery system in accordance with an embodiment of the present invention; Fig. 8 shows the guide cover disengaging from the orienter, in accordance with an embodiment of the present invention; Fig. 9 shows further compression of the valve prosthesis due to the guide cap, in accordance with an embodiment of the present invention; Fig. 10 shows the valve prosthesis being loaded into the guide cap in accordance with an embodiment of the present invention; Fig. 11 shows the valve prosthesis being received in the guide tube, in accordance with an embodiment of the present invention; eFig. 12 shows the valve prosthesis being fully loaded into the delivery system in accordance with an embodiment of the present invention. DETAILED DESCRIPTION
    [00018] Exemplary embodiments of the present invention will be described below with reference to the accompanying drawings. Although various details of embodiments of the present invention are mentioned in the detailed description below, for ease of understanding, they are to be interpreted as illustrative only. Therefore, it should be appreciated by those of ordinary skill in the art that the modalities described herein are susceptible to various changes and modifications, without departing from the scope and spirit of the present invention. Still, in the interest of clarity and brevity, the description of some well-known functions and structures is omitted.
    [00019] In one embodiment, the device for loading an implant into a delivery system, according to the present invention, includes a guide cap, a guide and a guide tube, which are described in greater detail below, with reference to accompanying drawings.
    [00020] Figs. 1A, 1B and 1C are schematic illustrations of a guide cover, according to an embodiment of the present invention, characterized in that Fig. 1A shows a profile of the guide cover, Fig. 1B is a cross-section taken along an axis of the guide cap, and Fig. 1C includes a perspective view of the guide cap and a diagram showing the guide cap when viewed along direction A. As shown in Figs. 1A and 1B, guide cap 1 has a conical section 101 and a straight or conical tube 103, which communicates with a small open end 102 of the conical section. A large open end 104 of the conical section spreads outwards, thereby forming a bead 105 facing the straight or conical tube 103. The bead 105 may define an annular groove 13. On the guide cover 1, a curved transition section 15 may connect the conical section 101 to the straight or conical tube 103 so that the guide cap 1 has a smooth interior surface to facilitate movement of the implant within the guide cap.
    [00021] The orienter has a circumferential wall, which has a circumferential surface that is tapered along an axis of the orienter, thereby forming a large opening at one end, and a small opening at the other end. The small opening has a diameter that is larger than a diameter of a free end 1031 of the straight or conical tube 103. In addition, the guide cap and the guide are so of such a size that the large open end of the guide can be covered by and secured by bead 105, with the sharp end 1031 passing through the orienter and protruding from the smaller opening of the orienter.
    [00022] The advisor can generally be a portion of a cone. However, in a preferred embodiment, as shown in Figs. 2A and 2B, the advisor consists of two tapered sections connected to each other. Figs. 2A and 2B schematically illustrate a preferred embodiment of an orienter, in accordance with an embodiment of the present invention, characterized in that Fig. 2B shows the orienter of Fig. 2A when viewed along direction A. As illustrated in Figs. . 2A and 2B, the orienter 2 has a first tapered section 9 and a second tapered section 10, which are joined together and respectively provide the large open end 8 and the small open end 11 of the advisor. At the interface 201 of tapered sections 9 and 10, the first tapered section 9 has a slightly larger diameter than a diameter of the second tapered section 10. That is, the guide 2 slightly shrinks in size in its middle portion. This prevents the implant from automatically escaping from the advisor and facilitates the prosthesis implant procedure.
    [00023] The rim 105 of the guide cover is coupled to the large open end of the orienter 2, by means of a force by means of friction, or the combination of bevels 17 of Fig. 1C and tables 12 of Fig. 2B. The chamfers 17 are disposed on the shoulder 105 and defined by several projections 171 projecting radially towards the tapered section 101 from the edge of the shoulder 105 (Fig. 1C). There are a plurality of protrusions 12 arranged in a plane defined by the edge of the large open end 8 of the orienter 2. As such, when the bead 105 covers the large open end 8 of the orienter 2, with the ridges 12 having passed through the respective chamfers 17 , properly rotating the bead 105 can make the protrusions 12 blocked by the respective protrusions 171, thereby locking the bead 105 and the guide 2 together.
    [00024] Figs. 3A and 3B schematically illustrate a guide tube in accordance with an embodiment of the present invention. Fig. 3A shows the external appearance of the guide tube, while Fig. 3B shows a cross-section of the guide tube. As shown in Fig. 3B, guide tube 3 includes a straight tube section 5 and a tapered tube section 7. Optionally, a curved transition section 6 can also be provided between sections 5 and 7 to ensure a smooth inner surface of the guide tube. 3. Alternatively, guide tube 3 can also be composed of one or two conical tube sections. In any case, the tapered tube section(s) is/are required to have a smaller taper angle. The open end of the tapered tubular section 7 has a diameter between a diameter of the small open end 102 of the tapered section 101 of the guide cap 1, and a diameter of the small open end 11 of the guide 2. The straight tubular section 5 may have an internal chamfer or fillet 4, on a free end to facilitate mounting with a catheter.
    [00025] With the previous device, according to embodiments of the present invention, an implant can be loaded into a delivery system through the following steps, as shown in Figs. 4 to 12. A description is mentioned below to explain how the device operates with reference to Figs. 4 to 12.
    [00026] The device according to the present invention can be used to load an implant such as a prosthetic heart valve into a delivery system such as a catheter. Fig. 4 shows such a valve prosthesis applicable to the embodiments of the present invention. As illustrated in Fig. 4, the valve prosthesis 18 has a flow end 19 and a valve flow end 20 provided with valve handles 27.
    [00027] Fig. 5 shows the implant being placed in an orienter according to an embodiment of the present invention. As shown in Fig. 5, the valve prosthesis 18 is first loaded into the guide 2 (along the direction as indicated by the arrow in the figure) such that the flow end of the valve 20 of the valve prosthesis 18 is introduced into the guide 2 , from the large open end 8 of the orienter 2, and protrudes from the small open end 11, with the flow end of the valve 19 being also exposed outside the large open end 8 of the orienter 2.
    [00028] Figs. 6A and 6B schematically illustrate guide cover and guide gear, in accordance with an embodiment of the present invention. As shown in Fig. 6A, the guide cover 1 and the guide 2 are first moved towards each other in opposite directions indicated by the arrows, so that the straight or conical tube 103 of the guide cover 1 enters the guide 2 from the large open end 8 and extends into valve prosthesis 18 in guider 2. Subsequently, as shown in Fig. 6B, free end 1031 of straight or conical tube 103 of guide cap 1 protrudes from small open end 11 of the orienter 2, thereby expanding the outflow end 20 of the valve prosthesis (as indicated by the arrow in Fig. 6B). In this case, the flow end 19 is received within the groove 13 (not shown in the figure) defined by the rim 105 of the guide cap 1, and the flow end 19 is thereby prevented from being undesirably deformed by any force.
    [00029] Fig. 7 schematically illustrates the coupling of the valve prosthesis to a delivery system, according to an embodiment of the present invention. As shown in Fig. 7, guide tube 3 is first disposed over a catheter 26 of the delivery system. The delivery system and the guide 2 carrying the valve prosthesis 18 are then moved in opposite directions towards each other (as indicated by the arrows in the figure). In this process, an end of the guide 24 of the delivery system enters the guide cap 1 from the free end 1031 of the straight or conical tube 103 of the guide cap 1 to enable the loops 23 to be engaged with the hooks 251 (with reference to Fig. 8) protruding from the surface of a connector 25 of the distribution system. Guide tube 3 is then moved to partially compress the prosthesis, and the delivery system catheter 26 is also moved so that the prosthesis is partially loaded into the catheter. Thereafter, the guide tube 3 is further moved to accommodate an additional portion of the implant, and this process can be repeated until no other portion of the implant can still be accommodated in the guide tube and loaded into the catheter due to a strong radial force, as shown in Fig. 8. In addition, since the diameter of the conical tubular section 7 at the open end is between the diameter of the straight or conical tube 103 at the free end 1031, and the diameter of the guide 2 at the small open end 11, in the configuration of Fig. 7, the movement of the guide tube 3 itself partially enters the guide 2 from the small open end 11 so that a portion of the implant is received in the guide tube and thereby is reduced in radial size. This facilitates the subsequent movement of the guide 2 in the right-hand direction as shown in Fig. 8, which is illustrating the schematic disengagement of the guide cover from the guide, in accordance with an embodiment of the present invention. As illustrated in Fig. 8, guide cover 1 and guide 2 are disengaged from each other and moved in opposite directions away from each other (as indicated by the two arrows in the figure).
    [00030] Fig. 9 further shows compression of the valve prosthesis due to the guide cap 1, according to an embodiment of the present invention. As shown in Fig. 9, guide cover 1 is oriented with bead 105 facing the tip of guide 24 of the dispensing system. In this state, moving the guide cap and dispensing system in opposite directions to each other (as indicated by the arrows in the figure) can lead to further compression of the flow end of the valve 19 as well as a proximal portion thereof. As a result, as shown in Fig. 10, the tip of the dispensing system guide 24 protrudes from the free end 1031 of the straight or conical tube 103 of the guide cap. Fig. 10 shows the valve prosthesis being received in the guide cap in accordance with an embodiment of the present invention.
    [00031] In the configuration of Fig. 10, when the guide tube 3 is moved along the direction indicated by the arrows, concurrently with the catheter 26 of the delivery system being held stationary, the guide cap 1 will be pulled out of the guide tube 3 , with the valve prosthesis 18 being accommodated in the guide tube 3, as shown in Fig. 11, which is a schematic illustration of the valve prosthesis being received in the guide tube 3, in accordance with an embodiment of the present invention.
    [00032] As shown in Fig. 11, when the delivery system catheter 26 is advanced in the direction indicated by the arrow to make both the delivery system connector 25 and the valve prosthesis located between the connector 25 and the tip of the delivery system guide 24 to enter the delivery system catheter 26. Then the valve prosthesis 18 will be fully loaded into the delivery system, as shown in Fig. 12, which is a schematic illustrating the valve prosthesis being fully loaded into the delivery system, in accordance with an embodiment of the present invention. In the configuration of Fig. 11 or 12, the guide 2 can be removed from the open end of the tapered tubular section 7 of the guide tube 3.
    [00033] As evident from the previous description of the process for loading the prostheses into the delivery system, the guide cover enables the valve prosthesis to be coupled to the delivery system connector, and allows the valve prosthesis to be compressed in such a way as to be fully received in the distribution system, with relatively easy and quick operations, thereby reducing the surgical time during its clinical use. In view of the structure of the device, according to the above modalities, the loading of the prosthetic valve can be carried out with only three components which are distinct in appearance without causing any confusion. The slight crease in the radial dimension of the guider in the middle portion, allows the valve prosthesis to be received in that place without leaking or causing interruptions. The guide tube having a relatively long tapered tubular section, or being implemented completely as a tapered tube provides protection for the delivery system catheter, and allows for a larger tubular opening, which is adapted to carry more types of valve prostheses in various forms. , more easily without causing injury to them. All of these advantages are beneficial in smooth operations during clinical use of the device in surgery.
    [00034] The specific embodiments presented above do not limit the scope of the present invention in any way. Those skilled in the art will appreciate that various modifications, combinations, sub-combinations and substitutions are still possible, depending on design requirements and other considerations. It is intended that all variations, substitutions and equivalent modifications made within the spirit and principles of the present invention fall within the scope of the present invention.
    权利要求:
    Claims (10)
    [0001]
    1. Device for loading an implant into a delivery system, the device comprising a guide cap (1), a guide (2) and a guide tube (3), characterized in that: the guide cap (1) has a conical section (101) and a straight or conical tube (103) in communication with a small open end (102) of the conical section (101), the conical section (101) having a large open end (104) which spreads out to outside and thereby forms a bead (105); the orienter (2) has a circumferential wall (9, 10) tapering along an axis of the orienter (2) and thus forms a large open end (8) in a first edge and a small open end (11) at a second edge of the circumferential wall (9, 10), the small open end (11) of the guide (2) having a diameter larger than a diameter of a free end ( 1031) of the straight or conical tube (103) of the guide cap (1); the guide cap (1) and the guide (2) are sized so that the rim (10 5) is capable of covering the large open end (8) of the advisor (2), with the free end (1031) of the straight or conical tube (103) protruding from the small open end (11) of the advisor (2 ); and the guide tube (3) is a round tube with a first and a second open end, the first open end having a diameter greater than the diameter of the small open end (102) of the conical section (101) of the guide cap (1) and smaller than the diameter of the small open end (11) of the orienter (2).
    [0002]
    2. Device according to claim 1, characterized in that: the edge (105) defines bevels (17); the orienter (2) has protrusions (12) on the first edge corresponding to the large open end (8); and the protrusions (12) match the bevels (17) when the guide cover (1) covers the guide (2).
    [0003]
    3. Device according to claim 1, characterized in that the bead (105) defines an annular groove (13) to receive an end of the implant.
    [0004]
    4. Device according to claim 1, characterized in that: the guide (2) has a first tapered section (9) and a second tapered section (10), each of the first and second tapered sections (9, 10 ) having a large open end and a small open end; the small open end of the first tapered section (9) has a diameter equal to or slightly smaller than a diameter of the large open end of the second tapered section (10) and is coupled to the large open end of second tapered section (10); large open end of first tapered section (9) provides large open end (8) of guide (2); and the small open end of the second tapered section (10) provides the small open end (11) of the guide (2).
    [0005]
    5. Device according to claim 1, characterized in that in the guide cap (1), a transition section (15) is provided between the conical section (101) and the straight or conical tube (103).
    [0006]
    6. Device according to claim 1, characterized in that the guide tube (3) is a tube with a tapered inner surface, a large open end of the tube providing the first open end of the guide tube (3).
    [0007]
    7. Device according to claim 1, characterized in that the guide tube (3) is a tube comprising a straight tubular section (5) and a conical tubular section (7), a large open end of the conical tubular section (7) providing the first open end of the guide tube (3).
    [0008]
    8. Device according to claim 7, characterized in that the guide tube (3) further comprises a transition section (6) between the straight tubular section (5) and the conical tubular section (7).
    [0009]
    9. Device according to any one of claims 1 to 8, characterized in that the implant is a heart valve stent.
    [0010]
    10. Method for loading an implant into a delivery system, the delivery system comprising a catheter (26), a connector (25) disposed at one end of the catheter (26), and a guide tip (24) coupled to the catheter (26) by a thin rod extending along an extended centerline of the catheter (26), characterized in that the method is implemented by the device as defined in any one of claims 1 to 8 and comprises the steps of: placing the implant in the guide (2) such that each end of the implant protrudes from a corresponding end of the guide (2); covering the guide (2) with the guide cap (1) such that the tube straight or conical (103) of the guide cap (1) extends through the implant, with the free end (1031) of the straight or conical tube (103) of the guide cap (1) protruding from the small open end (11) the advisor (2); arrange the guide tube (3) over the catheter (26) of the distribution system; Connect the guide tip (24) of the delivery system to the straight or conical tube (103) of the guide cap (1), and then couple the implant to the connector (25) of the delivery system and move the catheter (26) of the delivery system and the guide tube (3) so that the implant is partially received in the catheter (26) and thus in the guide tube (3); arrange the large open end (104) of the conical section (101) of the guide cap (1) over an end portion of the implant that is not received in the catheter (26) and move the guide cap (1) with respect to the catheter (26) such that the end portion of the implant is compressed and received in the tube straight or conical (103) of the guide cap (1), and then moving the guide tube (3) such that the implant is entirely received in the guide tube (3); moving the catheter (26) such that the implant is also entirely received in the catheter (26).
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    法律状态:
    2020-03-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-06-29| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-24| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/10/2014, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    CN201310534075.3A|CN104586542B|2013-10-31|2013-10-31|A kind of apparatus and method that implant is loaded in induction system|
    CN201310534075.3|2013-10-31|
    PCT/CN2014/089979|WO2015062534A1|2013-10-31|2014-10-31|Device and method for loading implant into delivery system|
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